Darren Aronofsky's harrowing, viscerally inventive portrait of addiction follows four people in Coney Island whose lives are consumed by their respective dependencies — heroin, diet pills, television, and the American Dream itself. Sara Goldfarb (Ellen Burstyn, in a career-defining performance), her son Harry (Jared Leto), his girlfriend Marion (Jennifer Connelly), and his friend Tyrone (Marlon Wayans) spiral downward in parallel degradations. Clint Mansell and Kronos Quartet's iconic score accompanies one of the most formally daring and emotionally devastating American films ever made.